SandboxLKT



Asp Receptor Ligand-binding domain

Overall structure

The ligand binding domain of the aspartate receptor (Initial view ) ) is a dimer of two 4-helix bundles that is shown here with the aspartate ligand bound. In this rainbow representation the N (blue) and C (red) termini are at the bottom of the structure; this is where the connections to the transmembrane helices have been truncated.

Ligand binding site

Interactions that stabilize ligand binding include hydrogen bonding from Tyr149 and Gln152 backbone carbonyls and Thr154 sidechain OH to the ligand amino group and hydrogen bonding from the sidechain nitrogens of Arg64, Arg69, and Arg73 to the two ligand carboxyl groups.